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One-pot synthesis of polycyclic isoindolines using isoindole umpolung. 2020

Rachel A Weintraub, and Wei He, and Xiang Wang
Department of Chemistry, University of Colorado, Boulder, CO 80309, USA.

Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the in situ-generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields.

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