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Lignans and Phenylethanoid Glycosides from the Aerial Parts of Pogostemon cablin. 2022
Jiaying Chen, and
Linhang Han, and
Guangxia Li, and
Liqin Sun, and
Fei Qian, and
Kaixian Chen, and
Liuqiang Zhang, and
Yiming Li
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Two new lignans (1-2) and a new octaketide (12), together with twenty-nine known compounds (3-11, 13-32) were isolated and identified from the aerial part of Pogostemon cablin. Their chemical structures were revealed mainly through NMR and MS data. The absolute configuration of 1 and 2 was deduced by comparing its experimental CD with the calculated ECD spectra. The inhibitory activities of the isolated compounds on LPS-stimulated nitric oxide (NO) production in RAW 264.7 cells were investigated. At a concentration of 25 μM, compounds 1 and 11 showed approximately equal NO inhibitory effects to that of aminoguanidine.
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