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SARS-CoV-2 IgG Antibody Levels in Women with IBD Vaccinated during Pregnancy. 2022

Irit Avni Biron, and Yair Maayan, and Tali Mishael, and Eran Hadar, and Michal Neeman, and Romina Plitman Mayo, and Hen Y Sela, and Simcha Yagel, and Rosalind Goldenberg, and Ami Ben Ya'acov, and Sorina Grisaru Granovsky, and Jacob E Ollech, and Hadar Edelman-Klapper, and Keren Masha Rabinowitz, and Maor H Pauker, and Henit Yanai, and Sophy Goren, and Dani Cohen, and Iris Dotan, and Ariella Bar-Gil Shitrit

Inflammatory Bowel Disease Center, Division of Gastroenterology, Rabin Medical Center, Petah-Tikva 4919001, Israel.

BACKGROUND Regulatory agencies supported vaccination of pregnant women with SARS-CoV-2 mRNA vaccines, including patients with IBD. No data exist regarding these vaccines in IBD during pregnancy. OBJECTIVE To assess the serologic response to two doses of the mRNA SARS-CoV-2 BNT162b2 vaccine in pregnant women with IBD vaccinated during pregnancy, compared to that of pregnant women without IBD, and non-pregnant women with IBD. METHODS Anti-spike antibody levels were assessed in all women and in cord blood of consenting women. RESULTS From December 2020 to December 2021, 139 women were assessed: pregnant with IBD-36, pregnant without IBD-61, and not pregnant with IBD-42. Antibodies were assessed in cords of two and nine newborns of women with and without IBD, respectively. Mean gestational ages at administration of the second vaccine doses were 22.0 weeks in IBD and 23.2 weeks in non-IBD, respectively. Mean (SD) duration from the second vaccine dose to serology analysis in pregnant women with IBD, without IBD, and in non-pregnant women with IBD was 10.6 (4.9), 16.4 (6.3), and 4.3 (1.0) weeks, respectively. All women mounted a serologic response. In multivariable analysis, no correlation was found between the specific group and antibody levels. In both pregnancy groups, an inverse correlation between antibody levels and the interval from the second vaccine dose was demonstrated. Cord blood antibody levels exceeded maternal levels in women with and without IBD. CONCLUSIONS All patients with IBD mounted a serologic response. The interval between vaccine administration to serology assessment was the most important factor determining antibody levels. A third vaccine dose should be considered in pregnant women with IBD vaccinated at early stages of pregnancy.