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Non-Hodgkin's lymphoma of the small intestine developed in a 66-year-old woman who was the wife of a man with transfusion-related acquired immune deficiency syndrome (AIDS). Antibody to the human T lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) was present in her serum, and the virus was isolated from her peripheral lymphocytes. The possibility that the non-Hodgkin's lymphoma in this patient was a manifestation of HTLV-III/LAV infection is discussed. This is believed to be the first reported case of lymphoma occurring in a patient with documented HTLV-III/LAV infection outside the male homosexual risk group.
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