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Dog IgG was produced by fractionation procedures used for the production of clinically used i.v. gammaglobulins. Chemical modification of dog IgG was done by pepsin or beta-propiolactone treatment. The intravascular half-life of beta-propiolactone IgG was 8.5 +/- 2.1 days compared to 4.5 +/- 1.6 days of pepsin treated IgG. Tissue concentrations of radioactive labelled beta-propiolactone IgG were generally higher than of pepsin digested IgG. Pepsin treated Igg was degraded to a significantly higher extent (26% of the administered radioactivity was bound to fragments smaller than 6000 MW after three days) than beta-propiolactone IgG (9% fragments after the same interval, P less than 0.001). It is concluded that the short intravascular half-life of pepsin IgG cannot be explained by increased extravascular filling, but is due to rapid degradation and excretion via the kidneys. There was no obvious difference in elimination and organ distribution between standard and beta-propiolactone IgG.
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J von Scheel, and
W Stephan, and
W Brendel
January 1986,
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J Ring, and
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T Bachmann, and
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W Brendel
January 1983,
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J Ring, and
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T Bachmann, and
J von Scheel, and
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W Brendel
January 1981,
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W Brendel
March 1973,
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W Brendel
November 1993,
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J von Scheel, and
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W Brendel
January 1976,
Journal of immunological methods,
J Ring, and
K H Duswald, and
T Bachmann, and
J von Scheel, and
W Stephan, and
W Brendel
February 2002,
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J Ring, and
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T Bachmann, and
J von Scheel, and
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W Brendel
January 1973,
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J Ring, and
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W Brendel
December 1976,
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J Ring, and
K H Duswald, and
T Bachmann, and
J von Scheel, and
W Stephan, and
W Brendel
January 1972,
Scandinavian journal of immunology,
