Biomaterial Database

In-vitro anti-Mycobacterium tuberculosis effect of Eugenol. 2022

C K Vidya Raj, and Jayapal Venugopal, and Muthuraj Muthaiah, and Vineet Kumar Chadha, and Usharani Brammacharry, and M Swappna, and A V Sangeetha, and Senthil Pragash Dhandapani, and Venkatasaiah Raman Kareedhi, and Latchoumycandane Calivarathan, and Mowna Karthick, and Karthick Jayapal

State TB Training & Demonstration Center, Intermediate Reference Laboratory, Government Hospital for Chest Diseases, Puducherry, 605006, India.

OBJECTIVE Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Therefore research on the detection of new antimicrobials against Mycobacterium tuberculosis is needed urgently. Essential oils extracted from plants have been shown to have anti-Mycobacterium tuberculosis effect in in-vitro experiments. Essential oil contains many chemicals and any one or more than one chemical may have the anti-Mycobacterium tuberculosis effect. Eugenol is one such chemical in the essential oil and the anti-Mycobacterium tuberculosis effect of eugenol is investigated. METHODS The anti-Mycobacterium tuberculosis effect of eugenol was evaluated against H37Rv and twelve clinical isolates of Mycobacterium tuberculosis in the BD BACTEC MGIT instrument using different volumes of eugenol. RESULTS H37Rv and all the twelve clinical isolates of Mycobacterium tuberculosis were inhibited by eugenol. The minimal inhibitory concentration of H37Rv was 2.5 μl (2.67 mg) and those of the clinical isolates of Mycobacterium tuberculosis ranged from to 2.5 μl (2.67 mg) to 10 μl (10.68 mg). CONCLUSIONS Eugenol has anti-Mycobacterium tuberculosis effect in the in-vitro BD BACTEC MGIT method.

UI	MeSH Term	Description	Entries
D008826	Microbial Sensitivity Tests	Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).	Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009169	Mycobacterium tuberculosis	A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.	Mycobacterium tuberculosis H37Rv
D009822	Oils, Volatile	Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.	Essential Oil,Oil, Essential,Oil, Volatile,Oils, Essential,Volatile Oil,Essential Oils,Volatile Oils
D005054	Eugenol	A cinnamate derivative of the shikimate pathway found in CLOVE OIL and other PLANTS.	Phenol, 2-methoxy-4-(2-propenyl)-
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014388	Tuberculosis, Lymph Node	Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.	Cervical Tuberculous Lymphadenitis,Lymphadenitis, Tuberculous,Mycobacterial Cervical Lymphadenitis,Scrofula,Cervical Lymphadenitis, Mycobacterial,Lymph Node Tuberculoses,Lymph Node Tuberculosis,Lymphadenitis, Cervical Tuberculous,Lymphadenitis, Mycobacterial Cervical,Scrofulas,Tuberculoses, Lymph Node,Tuberculous Lymphadenitis,Tuberculous Lymphadenitis, Cervical