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To assess the usefulness of cord blood tests in diagnosing ABO-haemolytic disease of the newborn (ABO-HDN), 132 term, adequate for gestational age (AGA) neonates were evaluated. The tests studied and their significant results were: quantitative elution test (greater than or equal to 1/16), direct Coombs test (positive), bilirubin concentration (greater than or equal to 4 mg/dl). In none of the 56 O+ newborn infants delivered by O+ women were the results of any test positive. Of the 76 A+ and B+ newborn infants delivered by O+ women, 17 (22%) developed ABO-HDN. When the combined result of any two tests was positive, the sensitivity, the specificity and the positive predictive accuracy for the diagnosis of ABO-HDN was higher than for any one of the isolated tests. The probability that ABO-HDN was present when the results of at least two cord blood tests were positive was 70%, and the probability that ABO-HDN was not present when less than two cord blood tests gave positive results was 93%. It is suggested that the combination of quantitative elution test, bilirubin concentration and direct Coombs test in the cord blood is useful for an early diagnosis of ABO-HDN.
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
March 1977,
Nursing mirror and midwives journal,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
January 1968,
Vox sanguinis,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
July 1982,
Medical laboratory sciences,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
May 2012,
Paediatrics and international child health,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
June 1958,
Archives of disease in childhood,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
January 1956,
Acta genetica et statistica medica,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
December 1969,
Vox sanguinis,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
July 1957,
Canadian Medical Association journal,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
November 1969,
Vox sanguinis,
R S Procianoy, and
C B Giacomini, and
D M Farina, and
G A Mollin, and
M I Winckler, and
M B Silveira, and
L Campos, and
J P Marques-Pereira
January 1965,
Vox sanguinis,
