-transparent.png){kind=logo}
3 alpha-Androstanediol glucuronide (3 alpha diol-G) is produced extrasplanchnically and is a good clinical marker of androgen action in peripheral tissues. However, the direct formation of androgen glucuronides in peripheral sites such as skin has not been determined in man. Genital skin from 21 premenopausal women and 8 men and foreskin from 6 neonates were incubated with either [14C]testosterone [14C]dihydrotestosterone (DHT) to determine the production of DHT glucuronide and 3 alpha diol-G in skin. After hydrolysis of incubation medium with glucuronidase, followed by extraction and sequential chromatography, constant 3H to 14C ratios of 3 alpha diol confirmed the production of DHT glucuronide and 3 alpha diol-g. The conversion of DHT to 3 alpha diol-G was higher than the conversion from testosterone (P less than 0.05), and conversion was higher in men than in women. These data provide evidence for the direct formation of C19 steroid glucuronides by human skin.
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
February 1993,
Journal of endocrinological investigation,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
May 1997,
Journal of endocrinological investigation,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
March 1997,
Journal of endocrinological investigation,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
August 1992,
The Journal of reproductive medicine,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
January 1991,
The Journal of clinical endocrinology and metabolism,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
December 1999,
Nihon rinsho. Japanese journal of clinical medicine,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
December 1997,
Wiener klinische Wochenschrift,
R A Lobo, and
W L Paul, and
E Gentzschein, and
P C Serafini, and
J A Catalino, and
R J Paulson, and
R Horton
November 1994,
European journal of endocrinology,
