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Lewis rats with experimental allergic encephalomyelitis (EAE) exhibited cell-mediated immunity to myelin basic protein as determined both with in vivo and in vitro assays. Positive skin test reactions and production of migration inhibitory factor (MIF) were observed before onset and after recovery from EAE. Rats rendered unresponsive to EAE exhibited in vitro cell-mediated immunity to basic protein, although in vivo manifestations were depressed. However, tolerant rats failed to respond to the encephalitogenic determinant; rats with EAE exhibited cell-mediated immunity to this region of the molecule. The results indicate that EAE-unresponsive rats possess lymphocytes capable of responding to basic protein, but that reactivity to the encephalitogenic peptide is suppressed.
T P McGraw, and
R H Swanborg
March 1984,
Cellular immunology,
T P McGraw, and
R H Swanborg
April 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T P McGraw, and
R H Swanborg
October 1983,
Cellular immunology,
T P McGraw, and
R H Swanborg
January 1977,
Immunological communications,
T P McGraw, and
R H Swanborg
June 1974,
Neurology,
T P McGraw, and
R H Swanborg
September 1983,
Journal of immunology (Baltimore, Md. : 1950),
T P McGraw, and
R H Swanborg
December 1978,
The Journal of experimental medicine,
T P McGraw, and
R H Swanborg
April 1980,
Annals of neurology,
T P McGraw, and
R H Swanborg
January 1971,
Research publications - Association for Research in Nervous and Mental Disease,
T P McGraw, and
R H Swanborg
January 1986,
Pathology and immunopathology research,
