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An intravenous injection of 2-fluoro-oestradiol simultaneously with an implantation-inducing dose of oestradiol reduced the number of implantation sites in delayed implanting hypophysectomized rats maintained with progesterone. Administration of 2-fluoro-oestradiol 1 h before or after oestradiol had no effect. Furthermore, injection of as much as 500 ng 2-fluoro-oestradiol 48 h before administration of oestradiol failed to have any effect upon implantation, i.e. failure to block implantation was correlated with failure to induce the uterine refractory state. These results suggest that conversion of primary oestrogens to catechol oestrogens could be important for implantation as well as for the induction of the oestrogen refractory state in the uterus.
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D C Johnson
January 1992,
Reproduction, fertility, and development,
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December 2009,
Brain research bulletin,
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D C Johnson
January 2001,
Experimental cell research,
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March 2001,
American journal of respiratory and critical care medicine,
S Long, and
S K Dey, and
D C Johnson
April 1985,
Brain research bulletin,
S Long, and
S K Dey, and
D C Johnson
August 1996,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
S Long, and
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D C Johnson
March 2007,
Clinical endocrinology,
S Long, and
S K Dey, and
D C Johnson
May 1975,
The Journal of endocrinology,
S Long, and
S K Dey, and
D C Johnson
January 1999,
Archives of toxicology,
S Long, and
S K Dey, and
D C Johnson
April 2009,
Anesthesiology,
