BIOMAT Database Logo BIOMAT Database Logo

KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells. 2023

Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Infantile hemangiomas are common vascular tumors with a specific natural history. The proliferation and regression mechanism of infantile hemangiomas may be related to the multilineage differentiation ability of hemangioma stem cells, but the specific mechanism is not well elucidated. KIAA1429 is an N6 -methyladenosine methylation-related protein that can also exert its role in a methylation-independent manner. This study aims to explore the function of KIAA1429 in infantile hemangiomas. qRT-PCR, western blotting, and immunostaining were performed to verify the expression of KIAA1429. The endothelial and fibroblast-like phenotypes of hemangioma endothelial cells were detected after KIAA1429 knockdown and overexpression. The stemness properties of hemangioma endothelial cells and the underlying mechanism of KIAA1429 in hemangiomas were also investigated. Nude mouse models of infantile hemangiomas were conducted to ascertain the effects of KIAA1429 in vivo. The results showed that KIAA1429 was highly expressed in infantile hemangiomas, particularly in involuting hemangiomas. In vitro experiments confirmed that KIAA1429 inhibited the endothelial phenotype, enhanced the differentiation ability, and promoted the fibroblast-like phenotype of hemangioma endothelial cells by inducing endothelial cell transition to facultative stem cells. However, the effect of KIAA1429 on the potential target was shown to be independent of N6 -methyladenosine methylation modification. Mouse models further revealed that KIAA1429 could inhibit the proliferation and promote the regression of hemangiomas. In conclusion, this study found that KIAA1429 played an important role in the regression of infantile hemangiomas by enhancing the stemness of hemangioma endothelial cells and could be a potential treatment target for infantile hemangiomas.

UI MeSH Term Description Entries
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D006391 Hemangioma A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000) Angioma,Chorioangioma,Hemangioma, Histiocytoid,Hemangioma, Intramuscular,Chorangioma,Chorangiomas,Chorioangiomas,Hemangiomas,Hemangiomas, Histiocytoid,Hemangiomas, Intramuscular,Histiocytoid Hemangioma,Histiocytoid Hemangiomas,Intramuscular Hemangioma,Intramuscular Hemangiomas
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D016601 RNA-Binding Proteins Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA. Double-Stranded RNA-Binding Protein,Double-Stranded RNA-Binding Proteins,ds RNA-Binding Protein,RNA-Binding Protein,ds RNA-Binding Proteins,Double Stranded RNA Binding Protein,Double Stranded RNA Binding Proteins,Protein, Double-Stranded RNA-Binding,Protein, ds RNA-Binding,RNA Binding Protein,RNA Binding Proteins,RNA-Binding Protein, Double-Stranded,RNA-Binding Protein, ds,RNA-Binding Proteins, Double-Stranded,ds RNA Binding Protein
D042783 Endothelial Cells Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer. Capillary Endothelial Cells,Lymphatic Endothelial Cells,Vascular Endothelial Cells,Capillary Endothelial Cell,Cell, Capillary Endothelial,Cell, Endothelial,Cell, Lymphatic Endothelial,Cell, Vascular Endothelial,Cells, Capillary Endothelial,Cells, Endothelial,Cells, Lymphatic Endothelial,Cells, Vascular Endothelial,Endothelial Cell,Endothelial Cell, Capillary,Endothelial Cell, Lymphatic,Endothelial Cell, Vascular,Endothelial Cells, Capillary,Endothelial Cells, Lymphatic,Endothelial Cells, Vascular,Lymphatic Endothelial Cell,Vascular Endothelial Cell
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression.
September 2017, The American journal of pathology,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Hemangioma Endothelial Cells and Hemangioma Stem Cells in Infantile Hemangioma.
February 2022, Annals of plastic surgery,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Endothelial progenitor cells in infantile hemangioma.
February 2004, Blood,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
August 2013, Experimental and therapeutic medicine,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Proliferating infantile hemangioma promotes α-fetoprotein production by HepG2 cells.
January 2020, Pediatric research,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Endothelial cells of intramuscular (infantile) hemangioma express glut1.
April 2007, International journal of surgical pathology,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
N-myc Downstream Regulated Gene 1 Promotes Adipocyte Differentiation in Endothelial Cells of Infantile Hemangioma.
June 2023, Annals of dermatology,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
[Isolation, culture and characterization of endothelial cells in infantile hemangioma].
March 2008, Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis.
October 2012, Experimental and therapeutic medicine,
Luying Wang, and Yuqing Zou, and Zhishun Huang, and Wenjing Wang, and Jing Li, and Jianhai Bi, and Ran Huo
Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.
August 2015, Biochemical and biophysical research communications,
Copied contents to your clipboard!