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Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan. 2023
Irene Molina-de la Fuente, and
María José Sagrado Benito, and
Laurence Flevaud, and
Janet Ousley, and
Harriet Akello Pasquale, and
Ahmed Julla, and
Abdirashid M Abdi, and
Buai Tut Chol, and
Bakri Abubakr, and
Agustín Benito, and
Cristian Casademont, and
Carolina Nanclares, and
Pedro Berzosa
Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for pfhrp3, and 7.5% for double deletions. Deletions were approximately twice as prevalent in monoclonal infections than in polyclonal infections.
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