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The pharmacokinetic properties of platelets make these vascular elements a potential and convenient model for serotoninergic neurons. Because we encountered several difficulties in preliminary platelet serotonin (5HT) uptake assays, we explored the influence of several assay factors on the parameters obtained. We found that a citrate-dextrose anticoagulant stabilized platelet 5HT uptake even at room temperature. More rapid wash rates during the filtration following the assay incubation gave higher apparent uptake affinities. Platelets from an inbred strain of rats exhibited less variability in Vmax than cells from outbred strains studied. These findings, in conjunction with a human twin study also suggesting that variance in platelet 5HT uptake increases with genetic diversification, demonstrate some additional confounding factors in platelet 5HT uptake studies.
E E Codd, and
R F Walker
June 1982,
Cephalalgia : an international journal of headache,
E E Codd, and
R F Walker
November 1983,
American heart journal,
E E Codd, and
R F Walker
October 1990,
Biological psychiatry,
E E Codd, and
R F Walker
January 1986,
Journal of affective disorders,
E E Codd, and
R F Walker
February 1975,
Experientia,
E E Codd, and
R F Walker
January 1984,
Neuropsychobiology,
E E Codd, and
R F Walker
March 1975,
Microvascular research,
E E Codd, and
R F Walker
January 1989,
International clinical psychopharmacology,
E E Codd, and
R F Walker
December 1984,
Cephalalgia : an international journal of headache,
E E Codd, and
R F Walker
June 2007,
Addiction biology,
