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We investigated the sustained effect of 12-week supplementation of 2.880 g/day of omega-3 fatty acids on platelet aggregability, platelet produced thromboxane B2 concentration and serum fatty acid composition in a double-blind controlled trial in 44 healthy mildly overweight eastern Finnish men recruited from a representative population sample. The supplementation was discontinued seven days before the biochemical measurements. Body weight, alcohol consumption and dietary composition remained constant during the study. Even though the percentage of eicosapentaenoic acid (20:5 omega 3) in total serum lipids increased by 37% (p less than 0.01) and that of dihomo-gamma-linolenic acid (20:3 omega 6) decreased by 18% (p less than 0.01) more in the omega-3 supplemented than placebo group during supplementation, there were no significant differences in the changes in either the ADP induced platelet aggregation or in vitro platelet produced thromboxane B2 concentration between the groups. These data suggest that omega-3 fatty acids have no detectable sustained effect either on ADP induced platelet aggregation or on thromboxane produced by the platelets in vitro.
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
January 2001,
World review of nutrition and dietetics,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
May 2022,
Human reproduction (Oxford, England),
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
May 2007,
Pharmacotherapy,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
February 2012,
Nutrition, metabolism, and cardiovascular diseases : NMCD,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
January 2008,
Reviews in obstetrics & gynecology,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
December 2012,
Journal of lipid research,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
September 2020,
Current nutrition reports,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
April 2012,
Atherosclerosis,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
January 2006,
MCN. The American journal of maternal child nursing,
R Salonen, and
T Nikkari, and
K Seppänen, and
J M Venäläinen, and
M Ihanainen, and
V Rissanen, and
R Rauramaa, and
J T Salonen
April 2020,
The Cochrane database of systematic reviews,
