[On the importance of cholesterol granuloma (author's transl)]. 1978

E Steinbach, and H Redianu

Cholesterol granuloma consists of solid metabolic waste products. The essential cause is a closed unaerated space in the middle ear cleft with proliferation of the mucosa, a connective tissue increased production of mucous and their subsequent organisation. During the resorption of this poorly digestable mucous cholesterol crystals are formed which in turn leads to small haemorrhages, increased fibrous tissue formation as well as the accumulation of foreign body giant cells. The analysis of 101 specimens showed different histological forms of cholesterol granuloma due to the different duration of the local pathological process. In the final stages the granulation tissue undergoes dystrophic calcification or necrosis. There is no influence on the adjacent bone. Cholesterol granuloma does not seem to be an important clinical entity. The therapy is the same as for the infectious process that is also present in the same ear.

UI MeSH Term Description Entries
D002781 Cholesteatoma A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL. Cholesteatomas
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D003238 Connective Tissue Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX. Connective Tissues,Tissue, Connective,Tissues, Connective
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004427 Ear Diseases Pathological processes of the ear, the hearing, and the equilibrium system of the body. Otologic Diseases,Otological Diseases,Disease, Ear,Disease, Otologic,Disease, Otological,Ear Disease,Otologic Disease,Otological Disease
D004432 Ear, Middle The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat. Tympanic Cavity,Tympanum,Middle Ear,Cavities, Tympanic,Cavity, Tympanic,Ears, Middle,Middle Ears,Tympanic Cavities,Tympanums
D005549 Foreign-Body Reaction Chronic inflammation and granuloma formation around irritating foreign bodies. Foreign Body Reaction,Reaction, Foreign-Body
D006099 Granuloma A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents. Granulomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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