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Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide. 2023
A Sofia Santos, and
Rita D Ferro, and
Nuno Viduedo, and
Luísa B Maia, and
Artur M S Silva, and
M Manuel B Marques
LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
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