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IgA concentrations in serum, sputum and bronchoalveolar lavage were determined in 11 patients with chronic obstructive lung disease exacerbated by infection and in 22 with similar disease during an infection-free period. Patients with infection had a higher serum-IgA concentration than those without. But there was no difference in sputum-IgA concentration between the two groups. Both for sputum and broncho-alveolar lavage there was a positive correlation between anti-elastolytic inhibition capacity and IgA concentration. In vitro it has been demonstrated that IgA concentration measured immunologically decreases with increasing elastase concentration, in line with increasing free elastolytic activity. Local IgA deficiency in patients with infection apparently results from proteolytic splitting of the immunoglobulin.
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
January 1989,
Allergologia et immunopathologia,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
February 1990,
Pneumologie (Stuttgart, Germany),
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
September 1996,
International archives of allergy and immunology,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
April 1988,
Nihon Kyobu Shikkan Gakkai zasshi,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
January 1997,
La Medicina del lavoro,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
February 1990,
Biulleten' eksperimental'noi biologii i meditsiny,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
March 1988,
Pneumonologia polska,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
September 1990,
The European respiratory journal,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
March 2015,
Journal of clinical microbiology,
T Schultek, and
J Braun, and
K J Wiessmann, and
W G Wood
June 2003,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
