-transparent.png){kind=logo}
Di(2-ethylhexyl)phthalate (DEHP) was administered to male rats in the diet at concentrations of 2.0, 0.2, and 0.02% for up to 102 weeks. Low doses resulted in moderate increases in certain hepatic enzymes during the initial phase of exposure and in a continuous increase in the activities of these same enzymes throughout the treatment period. An increased level of dolichol and decreased concentration of dolichyl-P were observed. Furthermore, the rate of protein glycosylation diminished. Liver biopsies from patients subjected to hemodialysis demonstrated an increased number of peroxisomes. Phthalate ester seems to interfere with protein turnover, so that the half-life of total mitochondrial and microsomal protein is considerably increased.
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1978,
Biochemical pharmacology,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
September 2021,
The Science of the total environment,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1973,
Environmental health perspectives,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
August 2016,
Environmental science and pollution research international,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
July 1992,
Toxicology and applied pharmacology,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1983,
Contributions to nephrology,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1978,
Journal of biochemistry,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1992,
Journal of cardiovascular pharmacology,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
November 1981,
Life sciences,
A E Ganning, and
U Brunk, and
C Edlund, and
A Elhammer, and
G Dallner
January 1976,
Journal of biochemistry,
