Biomaterial Database

Alteration in monocyte function in patients with breast cancer. 1987

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

University Department of Surgery, Royal Liverpool Hospital, UK.

Migration, phagocytosis and lysozyme production of peripheral monocytes from 36 patients with breast carcinoma was compared with a group of 36 healthy controls. A significant reduction in monocyte random migration and migration towards a chemotactic agent (P less than 0.001) was observed in patients with breast cancer. Furthermore monocyte phagocytic activity was also significantly decreased (P less than 0.001) in breast cancer patients compared to the controls. In contrast lysozyme production by peripheral monocytes was significantly increased in patients with breast cancer compared to controls (P less than 0.001). The changes in monocyte function in patients with breast carcinoma were not due to abnormal blood biochemistry or to direct continuous serum inhibitors, suggesting that the defect may be intrinsic. This defect in monocyte function may play an important role in the control of malignancies by cellular immune processes.

UI	MeSH Term	Description	Entries
D008597	Menstrual Cycle	The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.	Endometrial Cycle,Ovarian Cycle,Cycle, Endometrial,Cycle, Menstrual,Cycle, Ovarian,Cycles, Endometrial,Cycles, Menstrual,Cycles, Ovarian,Endometrial Cycles,Menstrual Cycles,Ovarian Cycles
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009000	Monocytes	Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.	Monocyte
D009113	Muramidase	A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	Lysozyme,Leftose,N-Acetylmuramide Glycanhydrolase,Glycanhydrolase, N-Acetylmuramide,N Acetylmuramide Glycanhydrolase
D010587	Phagocytosis	The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).	Phagocytoses
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002465	Cell Movement	The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.	Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults

Related Publications

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Irradiation and monocyte function in patients with breast cancer.

January 1979, International journal of radiation oncology, biology, physics,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Alteration in platelet function in patients with early breast cancer.

January 2005, Anticancer research,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Monocyte function in cancer patients.

January 1977, European journal of cancer,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Alteration of monocyte function following major injury.

March 1988, Archives of surgery (Chicago, Ill. : 1960),

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Abnormal monocyte function in bladder cancer patients.

May 1976, The Journal of urology,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Monocyte-derived giant cell formation in patients with breast cancer.

June 1991, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Identification of Rad51 alteration in patients with bilateral breast cancer.

January 2000, Journal of human genetics,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Alteration of Thyroid Function in Indian HER 2-Negative Breast Cancer Patients Undergoing Chemotherapy.

January 2015, Asian Pacific journal of cancer prevention : APJCP,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

[Monocyte function in patients with lymphomas].

January 1985, Sangre,

A M Al-Sumidaie, and S J Leinster, and D J Webster, and S A Jenkins

Peripheral Blood Monocyte Abundance Predicts Outcomes in Patients with Breast Cancer.

May 2022, Cancer research communications,