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Two proteins of molecular weights 25 and 12 kDa (p25 and p12 respectively), whose expression is regulated by testosterone, were identified in mouse ventral prostate. An antiserum raised to mouse ventral prostate secretion was used to demonstrate that p25 corresponds to the major secretory glycoprotein in mouse prostatic fluid. This antiserum does not cross-react with the major secretory proteins of the rat ventral prostate. Western blot analysis of mouse ventral prostate proteins using the prostatic secretion antiserum demonstrates that p12 and p25 are detectable at 3 weeks of age, but the maximum level of both proteins is not attained until 5 weeks of age. In addition, synthesis of p25 was also observed in prostate tissue derived from differentiated embryonic urogenital sinus tissue growing as implants under the renal capsule of syngeneic male hosts.
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
January 1990,
Andrologia,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
November 1997,
Proceedings of the National Academy of Sciences of the United States of America,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
February 1997,
Seminars in cancer biology,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
May 2006,
The Prostate,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
August 1996,
The Journal of steroid biochemistry and molecular biology,
J S Mills, and
M Needham, and
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M G Parker
December 1998,
The Prostate,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
June 1982,
Molecular and cellular endocrinology,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
December 1998,
Cancer research,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
April 1998,
Endocrinology,
J S Mills, and
M Needham, and
T C Thompson, and
M G Parker
July 1988,
Molecular biology and evolution,
