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Sixteen patients with locally advanced or metastatic head and neck cancer were treated with esorubicin (4'-deoxydoxorubicin) at a dose of 30-35 mg/m2 i.v. every 3 weeks. One patient was lost to the follow up after one cycle, whereas in the 15 evaluable cases a total of 34 courses were administered (median per patient: 2, range: 1-6). Pretreatment for parameter lesions consisted of radiotherapy in 5, chemotherapy in 3 and both treatments in 1 patients respectively. Overall, one partial response, one stable disease and 13 progressions were documented. Severe (grade 3 and 4) leukopenia, thrombocytopenia and anemia were noted in 3, 1 and 1 patients respectively. The only patient developing leukopenia and thrombocytopenia of grade 4 subsequently died because of pneumonia. On the other hand, non-hematologic toxicity was generally mild. At this dose and schedule, esorubicin demonstrated an activity less than 20% in head and neck cancer and therefore, no further evaluation is warranted.
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
February 1991,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
July 1989,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
November 1989,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
June 1990,
American journal of clinical oncology,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
September 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
January 1983,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
August 1990,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
April 1989,
Clinical pharmacology and therapeutics,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
January 1986,
Investigational new drugs,
S Frustaci, and
G Gasparini, and
A Veronesi, and
U Tirelli, and
M A Pacciarini, and
D Crivellari, and
V Zagonel, and
S Monfardini
February 1989,
Cancer,
