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A controversy exists with regard to the relative efficacy of two preparations of silver sulfadiazine (AgSD), Silvadene and Flint's Silver Sulfadiazine Cream. We compared the susceptibility of Staphylococcus aureus and clinical Gram-positive cocci, Gram-negative rods, and mixed floral isolates by the Nathan's agar well diffusion method and found no differences. However, when S aureus-infected rat burn wounds were treated with these antimicrobial creams over a period of ten days, Silvadene significantly lowered bacterial counts, whereas results after treatment with Flint's Silver Sulfadiazine Cream were no different from those of the control group, which received no treatment. These data imply that Silvadene controls S aureus-generated burn wound infections better than the Flint product.
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
January 1990,
The Journal of burn care & rehabilitation,
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
October 2013,
International wound journal,
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
January 1987,
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V Velanovich, and
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S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
June 1974,
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V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
December 2011,
Journal of wound care,
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
May 1975,
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V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
January 1971,
Surgical forum,
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
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R Schileru
September 1978,
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V Velanovich, and
J P Heggers, and
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T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
January 1986,
The Journal of burn care & rehabilitation,
V Velanovich, and
J P Heggers, and
M C Robson, and
S M Zoellner, and
T P McHugh, and
J Boertman, and
X T Niu, and
R Schileru
October 1984,
Burns, including thermal injury,
