Erythorbic acid content in tissues of guinea pigs administered erythorbic acid. 1987

E Suzuki, and T Kurata, and M Koda, and N Arakawa
Department of Food and Nutrition, Ochanomizu University, Tokyo, Japan.

The erythorbic acid (ErA) content in the tissues of guinea pigs administered ErA was compared with that of ascorbic acid (AsA). Guinea pigs were administered 1, 5, 20, and 100 mg ErA/day or 1, 5, and 100 mg AsA/day for 16 days and then sacrificed. The liver, adrenal glands, spleen, and kidneys were removed to determine the contents of ErA and AsA using HPLC. Only a small amount of ErA was found in four tissues of the animals administered 20 mg or more of ErA/day. On the contrary, AsA was found in the tissues of all animals administered 1 mg or more of AsA/day. The ErA content in the tissues was much lower than that of AsA even when the amount of ErA administered was the same as that of AsA. However, the body weight gains of animals administered ErA were similar to those of animals administered AsA. These observations suggested that the mechanism of the retention of ErA in the tissues was much different from that of AsA and that the vitamin C activity of ErA might be more than one-twentieth that of AsA.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000311 Adrenal Glands A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS. Adrenal Gland,Gland, Adrenal,Glands, Adrenal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

E Suzuki, and T Kurata, and M Koda, and N Arakawa
February 1974, Experientia,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
November 1969, Antibiotiki,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
February 1979, Endokrinologie,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
October 1969, Oral surgery, oral medicine, and oral pathology,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
August 1956, The Journal of investigative dermatology,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
September 2010, Inhalation toxicology,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
January 1966, Periodontics,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
January 1981, The American journal of clinical nutrition,
E Suzuki, and T Kurata, and M Koda, and N Arakawa
April 1994, Digestive diseases and sciences,
Copied contents to your clipboard!