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The promoting efficacies of N-acyl derivatives of amino acids on the rectal absorption of sodium ampicillin were investigated using the rat rectal loop technique. N-Acyl derivatives with longer carbon chains in the acyl moiety showed a greater promoting potency. The promoting potencies of N-acyl derivatives of phenylglycine and phenylalanine were greater than those of glycine and alanine derivatives when compared at the same length of carbon chain in their acyl moieties. The promoting action of N-acylamino acids was not influenced by the presence of N-ethylmaleimide or ouabain. The promoting potencies of N-acylamino acids were depressed in the presence of calcium chloride in the rectal loop. The contribution of the calcium ion sequestration capacity of N-acylamino acids to their promoting efficacies is discussed.
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
April 1988,
Pharmaceutisch weekblad. Scientific edition,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
June 1984,
Chemical & pharmaceutical bulletin,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
May 1984,
Chemical & pharmaceutical bulletin,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
July 1997,
Pharmaceutical research,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
April 1995,
Biological & pharmaceutical bulletin,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
November 1989,
The Journal of pharmacology and experimental therapeutics,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
November 1994,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
July 1991,
Journal of pharmacobio-dynamics,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
July 1988,
Pharmaceutical research,
W M Wu, and
T Murakami, and
Y Higashi, and
N Yata
May 1989,
Drug design and delivery,
