Multi-functional carboxymethyl chitosan/sericin protein/halloysite composite sponge with efficient antibacterial and hemostatic properties for accelerating wound healing. 2023

Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.

The development of wound dressings with hemostatic and antibacterial properties has attracted great attention. In this study, we prepared a multi-functional natural substance sponge (CMC/Ser-Ag/HNT) composed of carboxymethyl chitosan (CMC), sericin-silver nanoparticle (Ser-Ag), and halloysite (HNT). CMC/Ser-Ag/HNT sponge was demonstrated to bear desired hygroscopicity, porosity, compressive strength and compressive stability, cytocompatibility, and hemocompatibility. The mechanical properties (compressive strength of 100 kPa) and hemostatic capacity (hemostasis time of 15 ± 3 s in the liver injury model and 12 ± 3 s in the caudal injury model) were enhanced by introducing HNT into the CMC sponge. Ser-Ag was synthesized in situ via the redox nature of tyrosine residues in sericin in a "one-step, green" way to enhance the antibacterial activity of the hybrid sponge against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In addition, the rat full-thickness skin defect model experiments demonstrated that the CMC/Ser-Ag/HNT4 sponge significantly promoted epithelialization and collagen formation. Immunofluorescence staining assays revealed that the composite sponge reduced inflammation by downregulating the expression of IL-6 and enhanced angiogenesis by upregulating VEGF expression. All the findings demonstrated the great potential of CMC/Ser-Ag/HNT sponge as versatile clinical wound dressing, especially for hemorrhagic and infected wounds.

UI MeSH Term Description Entries
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D006487 Hemostasis The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION. Hemostases
D006490 Hemostatics Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. Antihemorrhagic,Hemostatic,Antihemorrhagics
D000077215 Clay A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter. Halloysite,Clays,Halloysites
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001458 Bandages Material used for wrapping or binding any part of the body. Dressings,Bandage,Dressing
D012834 Silver An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings

Related Publications

Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
April 2024, International journal of biological macromolecules,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
February 2022, Carbohydrate polymers,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
February 2023, Bioactive materials,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
January 2022, Colloids and surfaces. B, Biointerfaces,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
November 2022, Journal of biomaterials applications,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
October 2020, International journal of biological macromolecules,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
September 2022, Carbohydrate polymers,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
November 2022, Carbohydrate polymers,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
December 2023, International journal of biological macromolecules,
Silei Li, and Min Jiang, and Yi Zhang, and Xinyu Xie, and Weili Li, and PiaoYe Ming, and Xueyu Jiang, and Binbin Yang, and Yun He, and Junliang Chen, and Gang Tao
October 2021, Nanomaterials (Basel, Switzerland),
Copied contents to your clipboard!