Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53. 2023

Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
Institute of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, P. R. China.

Ginkgo biloba, as a medicinal plant in both traditional and western medicine, emerged as a potential therapeutic agent for the management of a variety of diseases, but ginkgo biflavones (bilobetin, isoginkgetin, and ginkgetin) application in cancer therapy and underlying mechanisms of action remained elusive. In the present study, we identified ginkgo biflavones as potential p53 activators that could enhance p53 protein expression level by inhibiting MDM2 protein expression. At the same time, they induced cell death independent of p53 transcriptional activity. Moreover, ginkgetin was a standout among ginkgo biflavones that reduced the survival of HCT-116 cells by induction of apoptosis and G2/M phase arrest. Furthermore, ginkgo biflavones induced ROS generation significantly, which resulted in ferroptosis. Finally, we provide evidence that ginkgetin strengthened the antitumor effect of fluorouracil (5-FU) in the HCT-116 colon cancer xenograft model. To sum up, ginkgo biflavones represent a new class of p53 activator that depends on the p53 wild-type status and warrants further exploration as potential anticancer agents.

UI MeSH Term Description Entries
D010946 Plants, Medicinal Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals. Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016159 Tumor Suppressor Protein p53 Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. p53 Tumor Suppressor Protein,Cellular Tumor Antigen p53,Oncoprotein p53,TP53 Protein,TRP53 Protein,p53 Antigen,pp53 Phosphoprotein,Phosphoprotein, pp53
D016923 Cell Death The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability. Death, Cell
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D020441 Ginkgo biloba The only specie of the genus Ginkgo, family Ginkgoacea. It is the source of extracts of medicinal interest, especially Egb 761. Ginkgo may refer to the genus or species. Gingko,Gingko biloba,Ginkgo,Ginkgophyta,Maidenhair Tree,Ginko,Gingko bilobas,Gingkos,Ginkgo bilobas,Ginkgophytas,Ginkgos,Ginkos,Maidenhair Trees,Tree, Maidenhair,Trees, Maidenhair,bilobas, Gingko,bilobas, Ginkgo

Related Publications

Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
September 1995, DNA and cell biology,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
June 2020, European journal of nutrition,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
January 2007, The Journal of biological chemistry,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
May 2010, Journal of molecular signaling,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
January 2020, Frontiers in oncology,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
August 2010, European journal of cancer (Oxford, England : 1990),
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
August 2005, Cancer research,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
August 1997, Proceedings of the National Academy of Sciences of the United States of America,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
July 2015, Blood,
Siyu Zhang, and Yujie Sun, and Fengli Yao, and Hongju Li, and Yacong Yang, and Xionghao Li, and Zhongyue Bai, and Yu Hu, and Peng Wang, and Ximing Xu
December 1994, Genes & development,
Copied contents to your clipboard!