Supply chains have been impacted by the COVID-19 pandemic, which is the most recent worldwide disaster. After the world health organization recognized the latest phenomena as a pandemic, nations became incapacitated to provide the required medical supplies. In the current situation, the world seeks an essential solution for COVID-19 Pandemic Wastes (CPWs) by pushing the pandemic to a stable condition. In this study, the development of a supply chain network is contrived for CPWs utilizing optimization modeling tools. Also, an IoT platform is devised to enable the proposed model to retrieve real-time data from IoT devices and set them as the model's inputs. Moreover, sustainability aspects are appended to the proposed IoT-enabled model considering its triplet pillars as objective functions. A real case of Puebla city and 15 experiments are used to validate the model. Furthermore, a combination of metaheuristic algorithms utilized to solve the model and also seven evaluation indicators endorse the selection of efficient solution approaches. The evaluation indicators are appointed as the inputs of statistical and multicriteria decision-making hybridization to prioritize the algorithms. The result of the Entropy Weights method and Combined Compromise Solution approach confirms that MOGWO has better performance for the medium-sizes, case study and an overall view. Also, NSHHO outclasses the small-size and large-size experiments.