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Rats were injected intraperitoneally with phenobarbital (PB) and 3-methylcholanthrene (MC), 80 and 20 mg/kg, respectively, for 3 consecutive days and then administered threshold lethal dose of the organophosphorus insecticide, parathion, 10 mg/kg i.p. to compare its toxicity in these, with those fed high fat, diet (HFD-50% saturated fat, and normal diet (ND-10% saturated fat) for 30 days. Hepatic microsomes of these four groups of rats without the parathion administration were also analysed to evaluate toxicity and metabolism of the insecticide in relation to some physico-chemical changes in microsomal membranes. Results showed that in comparison to ND, all three pretreatments (PB, MC and HFD) significantly decreased parathion toxicity, increased microsomal oxidase activity and elevated microsomal cholesterol/phospholipid ratio. However, microsomal cytochrome P-450 was significantly raised only in PB and MC, and microsomal fluidity was significantly raised only in MC, as measured by DPH-fluorescence polarization technique.
T Purshottam, and
R K Srivastava
February 1978,
Biochemical pharmacology,
T Purshottam, and
R K Srivastava
January 1987,
Hepatology (Baltimore, Md.),
T Purshottam, and
R K Srivastava
August 1987,
The Biochemical journal,
T Purshottam, and
R K Srivastava
February 1983,
Life sciences,
T Purshottam, and
R K Srivastava
April 1990,
Chemistry and physics of lipids,
T Purshottam, and
R K Srivastava
March 1970,
Bulletin of environmental contamination and toxicology,
T Purshottam, and
R K Srivastava
September 1997,
Cell biochemistry and function,
T Purshottam, and
R K Srivastava
January 1982,
Journal of lipid research,
T Purshottam, and
R K Srivastava
June 1973,
Analytical biochemistry,
T Purshottam, and
R K Srivastava
January 1968,
Archiv fur Geschwulstforschung,
