Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis. 2023

Karin R Vevang, and Lin Zhang, and Alex E Grill, and Dorothy K Hatsukami, and Ellen Meier, and Sarah Oppeneer Nomura, and Kim Robien, and Lisa A Peterson
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.

UI MeSH Term Description Entries
D002188 Cannabis The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber. Bhang,Ganja,Hashish,Hemp,Cannabis indica,Cannabis sativa,Hemp Plant,Marihuana,Marijuana,Bhangs,Cannabi,Ganjas,Hashishs,Hemp Plants,Hemps,Plant, Hemp,Plants, Hemp
D005663 Furans Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran. Tetrahydrofurans
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014026 Nicotiana A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; the dried leaves of Nicotiana tabacum are used for SMOKING. Tobacco Plant,Nicotiana tabacum,Plant, Tobacco,Plants, Tobacco,Tobacco Plants
D015415 Biomarkers Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc. Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune
D062789 Tobacco Products Substances and products derived from NICOTIANA TABACUM. Cigarettes,Cigars,Bidis,Bidis Tobacco,Cigarillos,Kreteks,Kreteks Tobacco,Pipe Tobacco,Tobacco, Bidi,Bidi,Bidi Tobacco,Bidi Tobaccos,Bidis Tobaccos,Cigar,Cigarette,Cigarillo,Kretek,Kreteks Tobaccos,Pipe Tobaccos,Product, Tobacco,Products, Tobacco,Tobacco Product,Tobacco, Bidis,Tobacco, Kreteks,Tobacco, Pipe,Tobaccos, Bidi,Tobaccos, Bidis,Tobaccos, Kreteks,Tobaccos, Pipe
D066300 Electronic Nicotine Delivery Systems Devices or objects designed to provide NICOTINE in the form of an inhaled aerosol. E-Cig,E-Cigarette,Electronic Cigarette,Electronic Cigarettes,Electronic Nicotine Delivery System,E-Cigarettes,E-Cigs,Cigarette, Electronic,Cigarettes, Electronic,E Cig,E Cigarette,E Cigarettes,E Cigs

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