This article compares the accuracy of intraoral scanners (IOSs) used in the digital impression of full arches to fabricate implant-supported complete prostheses. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered in the Open Science Framework (DOI 10.17605/OSF.IO/CPM9K). Six electronic databases, gray literature databases, and a manual search were performed in April 2022. Studies that evaluated the accuracy of intraoral scan impressions compared with conventional impressions in full-arch impressions were included for complete implant-supported prostheses. In addition, an adapted checklist for reporting in vitro studies was used to assess the risk of bias. Meta-analysis was conducted using a random-effects Hunter- Schmidt model. Nine studies were included in the analysis. IOS impressions present higher accuracy (137.86 μm) than conventional impressions (182.51 μm) (p<0.001). The heterogeneity of the study's methodology was I2¼18.34. However, impression accuracy varies significantly with scan body type, IOS type, scanning strategy, and modification technique. For most IOS systems, the acceptable clinical threshold of linear accuracy of 200 μm can be achieved, except for the True Definition Scanner in one of the studies. Based on the results of the included studies, digital impressions using IOS present similar or better linear accuracy than conventional impression techniques.