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Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 microgram/kg/h)-stimulated gastric acid output (P less than 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 +/- 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 +/- 12%. The mean integrated release of secretin response to duodenal acidification (3.9 +/- 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 +/- 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
December 1994,
Gastroenterology,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
January 1990,
Digestion,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
April 1963,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
November 1989,
Scandinavian journal of gastroenterology,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
January 1971,
Scandinavian journal of gastroenterology,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
September 1987,
The American journal of physiology,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
February 2002,
Peptides,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
June 1985,
Revista espanola de las enfermedades del aparato digestivo,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
April 1991,
Gastroenterology,
F Lluis, and
G Gomez, and
M Fujimura, and
G H Greeley, and
C M Townsend, and
J C Thompson
September 1971,
The American journal of physiology,
