-transparent.png){kind=logo}
Gastric ulcerations induced in rats by a combination of indomethacin and cold-stress (5 +/- 1 degrees C) for 6 hr were more severe than those induced by indomethacin or cold-stress alone. The acidity of gastric juice was increased in rats treated with indomethacin plus cold-stressed. Histamine H2 receptor antagonists, (H+-K+) ATPase inhibitors and prostaglandins inhibited gastric ulcer formation in indomethacin plus cold-stress treated rats, whereas anticholinergics aggravated the ulceration. The indomethacin plus cold-stress induced acid secretion was inhibited by cimetidine and omeprazole in pylorus-ligated rats. Atropine had less effect on the increase in acidity than cimetidine and omeprazole. These findings indicate that the ulcer formation in indomethacin plus cold-stress treated rats is related the increased in acidity of gastric juice. This gastric ulcer model may be useful for evaluating antiulcer agents.
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
August 1971,
Archives internationales de pharmacodynamie et de therapie,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
January 1975,
European journal of pharmacology,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
October 1986,
Pharmacology, biochemistry, and behavior,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
June 1993,
African journal of medicine and medical sciences,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
January 2004,
Journal of ethnopharmacology,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
March 1998,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
January 1992,
Journal of clinical gastroenterology,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
March 2023,
Biomedicines,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
March 1978,
Toxicology and applied pharmacology,
I Arai, and
H Hirose, and
C Usuki, and
M Muramatsu, and
H Aihara
May 2019,
Toxicology,
