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This study was undertaken to evaluate the possible cytotoxic effect of formaldehyde on the nasal mucosa in man. 38 men with an average age of 38 years and average exposure time of 10.5 years were studied. They were exposed to formaldehyde when processing laminae. All men passed a medical examination and a nasal biopsy. The histological findings were scored, 0-8, according to a system proposed by Torjussen. The findings were compared with a non-exposed reference group of 25 men (mean age 35 years). 35% of the exposed were smokers compared to 48% of the nonexposed. The average histological score was 2.8 for the exposed versus 1.8 for the non-exposed (p less than 0.05, Wilcoxon). The more common findings in the exposed were loss of cilia, goblet cell hyperplasia and squamous metaplasia. In four cases (11%) there was a mild dysplasia. Smoking had a slight modifying effect on the histological picture. The results indicate that the suspected precancerous findings in animal studies after exposure to formaldehyde might be present in workers exposed to formaldehyde at relatively low levels.
C Edling, and
H Hellquist, and
L Odkvist
November 1984,
International journal of cancer,
C Edling, and
H Hellquist, and
L Odkvist
January 1991,
British journal of industrial medicine,
C Edling, and
H Hellquist, and
L Odkvist
March 1987,
Rhinology,
C Edling, and
H Hellquist, and
L Odkvist
February 1989,
Journal of applied toxicology : JAT,
C Edling, and
H Hellquist, and
L Odkvist
June 2018,
Head and neck pathology,
C Edling, and
H Hellquist, and
L Odkvist
August 1983,
Toxicology and applied pharmacology,
C Edling, and
H Hellquist, and
L Odkvist
January 1980,
Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete,
C Edling, and
H Hellquist, and
L Odkvist
January 2014,
La Medicina del lavoro,
C Edling, and
H Hellquist, and
L Odkvist
January 1951,
Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie,
C Edling, and
H Hellquist, and
L Odkvist
January 1976,
Allergie und Immunologie,
