Endovascular Therapy for Basilar Artery Occlusion. 2023

Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (F.A.).

Basilar artery occlusion is one of the most devastating neurological conditions with high risks of disability and mortality. Despite the overwhelming benefit of endovascular therapy (EVT) in the anterior circulation and observational data supporting the efficacy of EVT in the posterior circulation, evidence from randomized controlled trials in basilar artery occlusion had been lacking until recently. The BEST (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment) and BASICS (Basilar Artery International Cooperation Study) randomized trials showed a nonsignificant direction of benefit but failed to demonstrate the superiority of EVT over standard medical therapy in basilar artery occlusion. However, these trials paved the way for 2 subsequent positive trials by highlighting the importance of consecutive recruitment, fast enrollment and avoidance or minimization of cross-over. The recently completed ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) and BAOCHE (Basilar Artery Occlusion Chinese Endovascular Trial) trials showed that EVT is beneficial for basilar artery occlusion within 24 hours of onset, with a treatment effect similar to what has been shown in anterior circulation large vessel occlusion ischemic stroke. In this topical review, we examine and contextualize the current evidence on EVT for basilar artery occlusion.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001157 Arterial Occlusive Diseases Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency. Arterial Obstructive Diseases,Arterial Occlusion,Arterial Obstructive Disease,Arterial Occlusions,Arterial Occlusive Disease,Disease, Arterial Obstructive,Disease, Arterial Occlusive,Obstructive Disease, Arterial,Occlusion, Arterial,Occlusive Disease, Arterial
D001488 Basilar Artery The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries. Arteries, Basilar,Artery, Basilar,Basilar Arteries
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes
D017131 Thrombectomy Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY. Aspiration Thrombectomy,Percutaneous Aspiration Thrombectomy,Aspiration Thrombectomies,Aspiration Thrombectomies, Percutaneous,Aspiration Thrombectomy, Percutaneous,Percutaneous Aspiration Thrombectomies,Thrombectomies,Thrombectomies, Aspiration,Thrombectomies, Percutaneous Aspiration,Thrombectomy, Aspiration,Thrombectomy, Percutaneous Aspiration
D057510 Endovascular Procedures Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY. Endovascular Techniques,Intravascular Procedures,Intravascular Techniques,Endovascular Procedure,Endovascular Technique,Intravascular Procedure,Intravascular Technique,Procedure, Endovascular,Procedure, Intravascular,Procedures, Endovascular,Procedures, Intravascular,Technique, Endovascular,Technique, Intravascular,Techniques, Endovascular,Techniques, Intravascular
D020521 Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) Apoplexy,Cerebral Stroke,Cerebrovascular Accident,Cerebrovascular Apoplexy,Vascular Accident, Brain,CVA (Cerebrovascular Accident),Cerebrovascular Accident, Acute,Cerebrovascular Stroke,Stroke, Acute,Acute Cerebrovascular Accident,Acute Cerebrovascular Accidents,Acute Stroke,Acute Strokes,Apoplexy, Cerebrovascular,Brain Vascular Accident,Brain Vascular Accidents,CVAs (Cerebrovascular Accident),Cerebral Strokes,Cerebrovascular Accidents,Cerebrovascular Accidents, Acute,Cerebrovascular Strokes,Stroke, Cerebral,Stroke, Cerebrovascular,Strokes,Strokes, Acute,Strokes, Cerebral,Strokes, Cerebrovascular,Vascular Accidents, Brain

Related Publications

Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
July 2022, Circulation,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
November 2023, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
May 2021, The New England journal of medicine,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
October 2022, The New England journal of medicine,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
January 2015, Interventional neurology,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
May 2021, The New England journal of medicine,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
September 2021, Journal of neurology, neurosurgery, and psychiatry,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
October 2021, Cardiovascular and interventional radiology,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
June 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Fana Alemseged, and Thanh N Nguyen, and Francisco Mont' Alverne, and Xinfeng Liu, and Wouter J Schonewille, and Raul G Nogueira
January 2022, Frontiers in neurology,
Copied contents to your clipboard!