Biomaterial Database

Oral Zn-DTPA treatment reduces cadmium absorption and retention in rats. 1987

K Kostial, and B Kargacin, and M Landeka

Institute for Medical Research and Occupational Health, Zagreb, Yugoslavia.

This work was performed to evaluate the possibility of using early oral diethylenetriaminepentaacetate (DTPA) therapy for decreasing absorption and retention of cadmium. Albino rats (6 days and 6 weeks old) were used. 115mCd was administered orally. Zn-DTPA was also given orally (3.64 mmol/kg) immediately after 115mCd and 24 h thereafter. Radioactivity in body and organs was determined 6 days later. In sucklings this treatment decreased whole body and gut retention 7-9 times and kidney and liver retention 2-3 times. In older rats it decreased whole body, gut and organ retention 4-5 times. This finding deserves attention since it is generally believed that DTPA is not indicated for early treatment, i.e. while the toxic metals or radionuclides are still in the gastrointestinal tract.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D002104	Cadmium	An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
D002105	Cadmium Poisoning	Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.	Itai-Itai,Poisoning, Cadmium,Cadmium Poisonings,Itai Itai,Poisonings, Cadmium
D002106	Cadmium Radioisotopes	Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.	Radioisotopes, Cadmium
D004369	Pentetic Acid	An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	DTPA,Diethylenetriamine Pentaacetic Acid,Pentetates,Penthanil,Ca-DTPA,CaDTPA,CaNa-DTPA,Calcium Trisodium Pentetate,DETAPAC,Indium-DTPA,Mn-Dtpa,Pentacin,Pentacine,Pentaind,Pentetate Calcium Trisodium,Pentetate Zinc Trisodium,Sn-DTPA,Zinc-DTPA,Indium DTPA,Pentaacetic Acid, Diethylenetriamine,Pentetate, Calcium Trisodium,Zinc DTPA
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus