[Conditioned reflexes in rats after 5-minute arrest of blood circulation]. 1987

N I Nezlina, and E A Mutuskina, and S V Tolova

Neurological recovery and conditioned activity were studied in rats resuscitated after five-minute circulation cessation caused by intrathoracal clamp of the heart vascular bundle. The dynamics of disappearance of neurological deficit was evaluated according a scale of 19 parameters of the general state of animals where number 100 meant the death of the brain and number 0 meant recovery. In the course of 8 months after resuscitation, in reanimated rats and simultaneously in intact (control) ones, an alimentary instrumental conditioned reflex was elaborated and then changed to a defensive one; passive and acute extinction of both reflexes was also carried out. In most of the rats the neurological recovery was completed rapidly within 3-4 hours. In reanimated animals, both instrumental conditioned reflexes were acquired in the same way as in the intact rats. Quantitative evaluation of the dynamics of conditioning and extinction allowed to see that elaboration of the alimentary reflex in reanimated rats proceeded faster and its change to the defensive one, and acute extinction of both kinds of conditioned reflexes went slower than in intact animals. A conclusion is drawn that even a short-term circulation cessation compatible with complete and rapid compensation of visible neurological disorders causes long-term disturbances of conditioned activity manifested in weakening of inhibitory processes.

UI MeSH Term Description Entries
D008297 Male Males
D009460 Neurologic Examination Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system. Examination, Neurologic,Neurological Examination,Examination, Neurological,Examinations, Neurologic,Examinations, Neurological,Neurologic Examinations,Neurological Examinations
D012151 Resuscitation The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed) Resuscitations
D002545 Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. Cerebral Ischemia,Ischemic Encephalopathy,Encephalopathy, Ischemic,Ischemia, Cerebral,Brain Ischemias,Cerebral Ischemias,Ischemia, Brain,Ischemias, Cerebral,Ischemic Encephalopathies
D003214 Conditioning, Classical Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus. Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D003216 Conditioning, Operant Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced. Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D006323 Heart Arrest Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation. Asystole,Cardiac Arrest,Cardiopulmonary Arrest,Arrest, Cardiac,Arrest, Cardiopulmonary,Arrest, Heart,Asystoles
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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