Cochlear blood flow in relation to age in normotensive and spontaneously hypertensive rats. 1987

M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
Department of Oto-Rhino-Laryngology, University Hospital, Uppsala, Sweden.

Cochlear blood flow was studied with the microsphere method in young and old normotensive and spontaneously hypertensive rats. The young animals were 3-6 months old and the old ones 18-24 months. The cochlear blood flow in young rats was 1.64 microliter/min/cochlea for the normotensive and 1.51 for the spontaneously hypertensive rats. In the old rats, the cochlear blood flow rates were 1.40 and 1.29 microliter/min/cochlea, respectively. The differences were not significant between the age groups, nor between the normotensive and spontaneously hypertensive rats. However, there was a tendency towards lower cochlear blood flow with increasing age, especially among the spontaneously hypertensive rats. The difference between young normotensive and old spontaneously hypertensive rats was significant (p less than 0.05). The group of old hypertensive rats was also the only one with evident morphological changes in the organ of Corti.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D003051 Cochlea The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH. Cochleas
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
January 1990, Acta oto-laryngologica,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
November 1988, Hearing research,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
March 1976, The American journal of physiology,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
May 1988, Hearing research,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
May 1976, Japanese heart journal,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
January 1984, Biomedica biochimica acta,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
January 1982, Hypertension (Dallas, Tex. : 1979),
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
January 1983, Acta oto-laryngologica,
M Hillerdal, and E Borg, and B Engström, and E Hultcrantz
January 1984, Scandinavian journal of urology and nephrology. Supplementum,
Copied contents to your clipboard!