BIOMAT Database Logo BIOMAT Database Logo

Efficacy of propranolol therapy after acute myocardial infarction related to coronary arterial anatomy and left ventricular function. 1987

S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Henry Ford Heart and Vascular Institute, Department of Medicine, Henry Ford Hospital, Detroit, Michigan 48202.

The effect of the beta-adrenergic blocking agent propranolol on morbidity and mortality risk after acute myocardial infarction was studied relative to coronary anatomy and left ventricular (LV) ejection fraction in a subset of 406 patients participating in a randomized study of 3,837 patients in the Beta Blocker Heart Attack Trial (BHAT). Median follow-up for this subset of patients was 28 months. The mortality rate was 2% (2 of 100) in patients with 2- and 3-vessel coronary artery disease taking propranolol and 10% (12 of 126) in those taking placebo (p less than 0.02). In patients with 2- and 3-vessel coronary artery disease with decreased LV function (defined as ejection fraction less than 50%), no patient taking propranolol died, whereas 17% (7 of 42) taking placebo died (p less than 0.04). The salutary effect of propranolol on mortality in the larger BHAT after acute myocardial infarction also was evident in this population studied in regard to their coronary and LV anatomy and function.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D011433 Propranolol A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D003331 Coronary Vessels The veins and arteries of the HEART. Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D013318 Stroke Volume The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume. Ventricular Ejection Fraction,Ventricular End-Diastolic Volume,Ventricular End-Systolic Volume,Ejection Fraction, Ventricular,Ejection Fractions, Ventricular,End-Diastolic Volume, Ventricular,End-Diastolic Volumes, Ventricular,End-Systolic Volume, Ventricular,End-Systolic Volumes, Ventricular,Fraction, Ventricular Ejection,Fractions, Ventricular Ejection,Stroke Volumes,Ventricular Ejection Fractions,Ventricular End Diastolic Volume,Ventricular End Systolic Volume,Ventricular End-Diastolic Volumes,Ventricular End-Systolic Volumes,Volume, Stroke,Volume, Ventricular End-Diastolic,Volume, Ventricular End-Systolic,Volumes, Stroke,Volumes, Ventricular End-Diastolic,Volumes, Ventricular End-Systolic

Related Publications

S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
[Coronary anatomy and left ventricular function in patients surviving acute myocardial infarction].
March 1985, Arquivos brasileiros de cardiologia,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Predictors of clinical course, coronary anatomy and left ventricular function after recovery from acute myocardial infarction.
November 1980, Circulation,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Left ventricular function after acute myocardial infarction.
January 1976, European journal of intensive care medicine,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Coronary collaterals and left ventricular function early after acute transmural myocardial infarction.
June 1982, European heart journal,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Relation of coronary arterial patency and left ventricular function to electrocardiographic changes after streptokinase treatment during acute myocardial infarction.
May 1988, The American journal of cardiology,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Influence of coronary arterial thrombus location on left ventricular function in acute myocardial infarction.
July 1990, The American journal of cardiology,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Coronary anatomy, left ventricular function and electrocardiographic stress testing three to four weeks after first myocardial infarction.
January 1988, Indian heart journal,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
A pooled analysis of coronary arterial patency and left ventricular function after intravenous thrombolysis for acute myocardial infarction.
December 1994, The American journal of cardiology,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Changes in coronary anatomy and left ventricular function from the acute to the chronic stage of myocardial infarction.
January 1980, Clinical cardiology,
S M Jafri, and F Khaja, and T McFarland, and R Capone, and S Dahdah, and J Haywood, and W A Edmiston, and B Tilley, and L Schultz, and S Goldstein
Ventricular arrhythmias, left ventricular function and mortality after acute myocardial infarction.
May 1986, European heart journal,
Copied contents to your clipboard!