Biomaterial Database

Localized activity alternations in periventricular nodular heterotopia-related epilepsy. 2023

Wenyu Liu, and Hesheng Zhang, and Xinyu Hu, and Dong Zhou, and Xintong Wu

Departments of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Periventricular nodular heterotopia (PNH) is a common type of heterotopia usually characterized by epilepsy. Previous studies have identified alterations in structural and functional connectivity related to this disorder, but its local functional neural basis has received less attention. The purpose of this study was to combine univariate analysis and a Gaussian process classifier (GPC) to assess local activity and further explore neuropathological mechanisms in PNH-related epilepsy. We used a 3.0-T scanner to acquire resting-state data and measure local regional homogeneity (ReHo) alterations in 38 patients with PNH-related epilepsy and 38 healthy controls (HCs). We first assessed ReHo alterations by comparing the PNH group to the HC group using traditional univariate analysis. Next, we applied a GPC to explore whether ReHo could be used to differentiate PNH patients from healthy patients at an individual level. Compared to HCs, PNH-related epilepsy patients exhibited lower ReHo in the left insula extending to the putamen as well as in the subgenual anterior cingulate cortex (sgACC) extending to the orbitofrontal cortex (OFC) [p < 0.05, family-wise error corrected]. Both of these regions were also correlated with epilepsy duration. Furthermore, the ReHo GPC classification yielded a 76.32% accuracy (sensitivity = 71.05% and specificity = 81.58%) with p < 0.001 after permutation testing. Using the resting-state approach, we identified localized activity alterations in the left insula extending to the putamen and the sgACC extending to the OFC, providing pathophysiological evidence of PNH. These local connectivity patterns may provide a means to differentiate PNH patients from HCs.

UI	MeSH Term	Description	Entries
D008279	Magnetic Resonance Imaging	Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.	Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D011699	Putamen	The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.	Nucleus Putamen,Nucleus Putamens,Putamen, Nucleus,Putamens,Putamens, Nucleus
D004827	Epilepsy	A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000087623	Insular Cortex	A pyramidal shaped region of cerebral cortex located deep below the lateral fissure in PRIMATES. It is surrounded by the SUPERIOR TEMPORAL GYRUS, the rostral PARIETAL LOBE, the INFERIOR FRONTAL GYRUS and the ORBITAL GYRI. It is the primary gustatory cortex and is involved in sensorimotor and somatosensory as well as socioemotional functions.	Brodmann Area 13,Brodmann Area 14,Brodmann Area 15,Brodmann Area 16,Brodmann Area 43,Brodmann's Area 13,Brodmann's Area 14,Brodmann's Area 15,Brodmann's Area 16,Brodmann's Area 43,Central Lobe,Gustatory Cortex,Insula of Reil,Insular Gyrus,Insular Region,Lobus Insularis,Opercular Cortex,Primary Gustatory Cortex,Visceral Cortex,Area 13, Brodmann,Area 13, Brodmann's,Area 14, Brodmann,Area 14, Brodmann's,Area 15, Brodmann,Area 15, Brodmann's,Area 16, Brodmann,Area 16, Brodmann's,Area 43, Brodmann,Area 43, Brodmann's,Brodmanns Area 13,Brodmanns Area 14,Brodmanns Area 15,Brodmanns Area 16,Brodmanns Area 43,Central Lobes,Cortex, Gustatory,Cortex, Insular,Cortex, Opercular,Cortex, Primary Gustatory,Cortex, Visceral,Gustatory Cortex, Primary,Gyrus, Insular,Insular Cortices,Insular Regions,Lobe, Central,Primary Gustatory Cortices,Region, Insular,Visceral Cortices
D054091	Periventricular Nodular Heterotopia	A disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches.	Bilateral Periventricular Nodular Heterotopia,Familial Nodular Heterotopia,Heterotopia, Familial Nodular,Heterotopia, Periventricular, X-Linked Dominant,Nodular Heterotopia, Bilateral Periventricular,Periventricular Heterotopia,Periventricular Heterotopia, X-Linked,Periventricular Nodular Heterotopia 1,Familial Nodular Heterotopias,Heterotopia, Periventricular,Heterotopia, Periventricular Nodular,Heterotopia, X-Linked Periventricular,Nodular Heterotopia, Familial,Nodular Heterotopia, Periventricular,Periventricular Heterotopia, X Linked,Periventricular Heterotopias,Periventricular Nodular Heterotopias,X-Linked Periventricular Heterotopia,X-Linked Periventricular Heterotopias