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Two patients with non-spherocytic hemolytic anemia were found to have elevated red blood cell pyruvate kinase activities commensurate with the decreased mean red cell age, but the residual pyruvate kinase had marked kinetic abnormalities. Accumulation of metabolic intermediates before pyruvate kinase and reduced levels of activity of the red blood cells of the parents of both patients supported the diagnosis of an inherited abnormal pyruvate kinase causing hemolytic anemia. Although it was observed in two unrelated persons, review of enzyme assays performed on the red blood cells of 651 patients with hereditary non-spherocytic hemolytic anemia suggests that this occurrence is rare.
E Beutler, and
L Forman, and
E Rios-Larrain
June 2007,
Haematologica,
E Beutler, and
L Forman, and
E Rios-Larrain
May 1979,
American journal of human genetics,
E Beutler, and
L Forman, and
E Rios-Larrain
December 1975,
Klinische Wochenschrift,
E Beutler, and
L Forman, and
E Rios-Larrain
June 1963,
La Presse medicale,
E Beutler, and
L Forman, and
E Rios-Larrain
June 1964,
Minerva medica,
E Beutler, and
L Forman, and
E Rios-Larrain
January 1970,
Archives francaises de pediatrie,
E Beutler, and
L Forman, and
E Rios-Larrain
August 1988,
Blood,
E Beutler, and
L Forman, and
E Rios-Larrain
May 1974,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
E Beutler, and
L Forman, and
E Rios-Larrain
June 1967,
Wiener klinische Wochenschrift,
E Beutler, and
L Forman, and
E Rios-Larrain
January 1982,
Acta chirurgica Belgica,
