A robust carbon dot-based antibacterial CDs-PVA film as a wound dressing for antibiosis and wound healing. 2023

Chengjian Mou, and Xinyuan Wang, and Yanchao Liu, and Zhigang Xie, and Min Zheng
School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, 2055 Yanan Street, Changchun, Jilin 130012, P. R. China. zhengm@ciac.ac.cn.

Developing highly effective antibacterial films to promote wound healing remains a huge challenge. Herein, homogeneous and self-standing CDs-PVA composite films (PVA3, PVA5 and PVA8) were constructed by doping various mass ratios (3, 5 and 8 wt%) of carbon dots (CDs) into polyvinyl alcohol (PVA), which had no cracks or macroscopic defects. Moreover, the robust mechanical strength and flexibility enabled them to be cut into diverse patterns as required, which provided unique advantages for being employed as a wound dressing. PVA5 and PVA8 were powerful broad-spectrum bactericides and they could kill both Gram-negative bacteria and Gram-positive bacteria like Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with the antibacterial efficacy over 90.0%. More significantly, the biocompatible films could be readily processed into a "band-aid" type dressing for wound healing. The PVA5 band-aids were just pasted on the wounds for two days and then removed, and the wounds were completely closed after fourteen days. Neither introducing any metals or antibiotics, nor with the help of any external activation, these kinds of CD-based films have the strengths of low cost, being easy to use, excellent biocompatibility and outstanding antibacterial performance, and are desirable wound dressings for various skin injuries.

UI MeSH Term Description Entries
D011142 Polyvinyl Alcohol A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products. Liquifilm Tears,Polyviol,Alcohol, Polyvinyl,Tears, Liquifilm
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D000898 Antibiosis A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another. Bacterial Interference,Microbial Antagonism,Interference, Bacterial,Antagonism, Microbial,Antagonisms, Microbial,Antibioses,Bacterial Interferences,Interferences, Bacterial,Microbial Antagonisms
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001458 Bandages Material used for wrapping or binding any part of the body. Dressings,Bandage,Dressing
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings

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