Resting metabolic rate (RMR) could represent metabolic health status. This study aims to examine the association of the predicted RMR with 1-year poor functional outcome and all-cause mortality in patients with ischemic stroke as a proxy of metabolic profile. A total of 15,166 patients with ischemic stroke or transient ischemic attack (TIA) from the Third China National Stroke Registry (CNSR-III) were enrolled in this study. The Harris-Benedict equation based on sex, age, weight, and height was used to predict RMR. The primary endpoints were poor functional outcome defined as ≥3 modified Rankin Scale (mRS) score and all-cause mortality within 1 year. The association between predicted RMR and prognosis was assessed by multivariable regression analysis. Besides that, subgroup analysis of age, sex, and body mass index (BMI) with predicted RMR was also performed. 12.85% (1657) individuals had poor functional outcome and 2.87% (380) died of whatever causes within 1 year. An inverse association was found between predicted RMR with poor functional outcome and all-cause mortality. Compared to the lowest quartile, the highest quartile was significantly associated with lower risk of poor functional outcome (adjusted odds ratio [OR], 0.43 [95% confidence interval (CI) 0.33-0.56]) and all-cause mortality (adjusted hazard ratio [HR], 0.44 [95% CI 0.28-0.71]). No significant interaction was between predicted RMR and specified subgroup. Predicted RMR by the Harris-Benedict equation seems to be an independent protective predictor of poor functional outcome and all-cause mortality after ischemic stroke as a metabolic proxy.