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While endocrine therapy is considered as an effective way to treat breast cancer, it still faces many challenges, such as drug resistance and individual discrepancy. Therefore, novel preventive and therapeutic modalities are still in great demand to decrease the incidence and mortality rate of breast cancer. Numerous studies suggested that G protein-coupled estrogen receptor (GPER), a membrane estrogen receptor, is a potential target for breast cancer prevention and treatment. It was also shown that not only endogenous estrogens can activate GPERs, but many phytoestrogens can also function as selective estrogen receptor modulators (SERMs) to interact GPERs. In this review, we discussed the possible mechanisms of GPERs pathways and shed a light of developing novel phytoestrogens based dietary supplements against breast cancers.
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Wenjing Xiao
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Shuo Huang, and
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Yonghe Hu, and
Wenjing Xiao
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Shuo Huang, and
Baowen Qi, and
Ling Yang, and
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Jing Huang, and
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Wenjing Xiao
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Shuo Huang, and
Baowen Qi, and
Ling Yang, and
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Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
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Shuo Huang, and
Baowen Qi, and
Ling Yang, and
Xue Wang, and
Jing Huang, and
Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
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Shuo Huang, and
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Ling Yang, and
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Shuo Huang, and
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Jing Huang, and
Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
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Shuo Huang, and
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Jing Huang, and
Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
December 1998,
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Shuo Huang, and
Baowen Qi, and
Ling Yang, and
Xue Wang, and
Jing Huang, and
Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
December 2002,
The Journal of steroid biochemistry and molecular biology,
Shuo Huang, and
Baowen Qi, and
Ling Yang, and
Xue Wang, and
Jing Huang, and
Ya Zhao, and
Yonghe Hu, and
Wenjing Xiao
June 2001,
Endocrine-related cancer,
