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An on-line computer technique is described for the detection and quantitation of left-to-right shunts. The computer used Student's t test to evaluate the probability that variations in right heart oxygen saturations were due to left-to-right shunts. The computer method was found to compare favorably to the present step-up method of detecting left-to-right shunts. The computer also calculated pulmonary blood flow, systemic blood flow, their ratio, and shunt blood flow as accurately as standard methods, as evidenced by correlation coefficients of 0.98, 0.94, 0.95, and 0.71 between the computer and hand calculations.
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