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Despite the fact that a considerable amount of albumin is present in bile, little is known about the effect of albumin on micellar solubility of cholesterol. The effect of albumin on solubility of cholesterol in various micellar bile salt solutions was studied using Millipore filtration after equilibration. In addition, partitioning of cholesterol from micellar solution was studied using a polyethylene disc method. Decrease of the solubility of cholesterol by the presence of albumin was observed only in unconjugated bile salt solution. The lowering effect of albumin on the cholesterol solubility was found to be proportional to the hydrophobicity of bile salt. In contrast, albumin had almost no effect on cholesterol solubility, either in conjugated bile salt solution or in micellar bile salt solution containing phosphatidylcholine. Addition of albumin enhanced the partitioning of cholesterol out of the micelles in sodium chenodeoxycholate solution as a result of decreased micellar solubility and increased the aqueous solubility of cholesterol in the presence of albumin. Therefore, conjugated bile salt and phosphatidylcholine exert a buffering action on the albumin-induced adverse effect on cholesterol solubility, thus stabilising bile against inadvertent precipitation of cholesterol.
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
February 1978,
The Tohoku journal of experimental medicine,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
August 1977,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
June 1983,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
December 1973,
The American journal of digestive diseases,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
September 1986,
Gastroenterology,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
June 1980,
Digestive diseases and sciences,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
May 2000,
Gastroenterology,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
August 1972,
Science (New York, N.Y.),
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
November 1968,
Arzneimittel-Forschung,
K Fukudome, and
K Chijiiwa, and
T Furusawa, and
F Nakayama
February 1974,
Gastroenterology,
