Biomaterial Database

Red nucleus lesions delay the evolution of amygdala kindling in cats. 1987

C Paz, and E Reygadas

Departamento de Fisiología, Facultad de Medicina, U.N.A.M., Tlalpan, Mexico.

There are some papers which claim that the red nucleus (RN) is related to epileptic manifestations. Though the lesion or electrographic recording of the RN include many paths which assemble into it, the possibility that its cells are implicated in epilepsy is deduced. This paper compares the evolution of amygdaloid kindling in cats with bilateral RN lesions, with the epileptic disturbances provoked by lesion or stimulation of approach cells. Due to the intrinsic error of the stereotaxic method, only 7 of 13 cats show lesions in the RN with a diameter extending down to 150 micron. Only these show a shortening of the afterdischarge duration, a delay in the appearance of the consecutive clinical stages, and a lengthening in the appearance of generalized tonic-clonic seizures. In comparison, the 6 other cats show lesions mainly in the adjacent central tegmental field, and their kindling evolution was similar to that of a control group with intact mesencephalon. We conclude that the RN lesions interfere with the kindling generation, presumably by lesioning the cerebello-cerebral paths which produce a depression of cortical activity, during the consolidation of clinical and electrographic manifestations.

UI	MeSH Term	Description	Entries
D007696	Kindling, Neurologic	The repeated weak excitation of brain structures, that progressively increases sensitivity to the same stimulation. Over time, this can lower the threshold required to trigger seizures.	Kindlings, Neurologic,Neurologic Kindling,Neurologic Kindlings
D009434	Neural Pathways	Neural tracts connecting one part of the nervous system with another.	Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D011846	Radio Waves	Electromagnetic waves with frequencies between about 3 kilohertz (very low frequency - VLF) and 300,000 megahertz (extremely high frequency - EHF). They are used in television and radio broadcasting, land and satellite communications systems, radionavigation, radiolocation, and DIATHERMY. The highest frequency radio waves are MICROWAVES.	Hertzian Waves,High Frequency Waves,Radiowave,Radiowaves,Short Waves,Very High Frequency Waves,Frequency Wave, High,Frequency Waves, High,High Frequency Wave,Radio Wave,Short Wave,Wave, High Frequency,Wave, Radio,Wave, Short,Waves, Hertzian,Waves, High Frequency,Waves, Radio,Waves, Short
D012012	Red Nucleus	A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.	Nucleus Ruber,Nucleus, Red
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D000679	Amygdala	Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.	Amygdaloid Body,Amygdaloid Nuclear Complex,Amygdaloid Nucleus,Archistriatum,Corpus Amygdaloideum,Intercalated Amygdaloid Nuclei,Massa Intercalata,Nucleus Amygdalae,Amygdalae, Nucleus,Amygdaloid Bodies,Amygdaloid Nuclear Complices,Amygdaloid Nuclei, Intercalated,Amygdaloid Nucleus, Intercalated,Amygdaloideum, Corpus,Amygdaloideums, Corpus,Archistriatums,Complex, Amygdaloid Nuclear,Complices, Amygdaloid Nuclear,Corpus Amygdaloideums,Intercalata, Massa,Intercalatas, Massa,Intercalated Amygdaloid Nucleus,Massa Intercalatas,Nuclear Complex, Amygdaloid,Nuclear Complices, Amygdaloid,Nuclei, Intercalated Amygdaloid,Nucleus, Amygdaloid,Nucleus, Intercalated Amygdaloid
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia