| D001792 |
Blood Platelets |
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. |
Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte |
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| D006160 |
Guanosine Triphosphate |
Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. |
GTP,Triphosphate, Guanosine |
|
| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
|
| D013927 |
Thrombosis |
Formation and development of a thrombus or blood clot in BLOOD VESSELS. |
Atherothrombosis,Thrombus,Blood Clot,Blood Clots,Thromboses |
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| D015398 |
Signal Transduction |
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. |
Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal |
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| D015539 |
Platelet Activation |
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
Activation, Platelet,Activations, Platelet,Platelet Activations |
|
| D020741 |
rho GTP-Binding Proteins |
A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47. |
rho G-Proteins,rho GTPase,rho GTPases,rho Small GTP-Binding Proteins,P21 (rho)Protein,rho GTP-Binding Protein,rho Protein P21,G-Proteins, rho,GTP-Binding Protein, rho,GTP-Binding Proteins, rho,GTPase, rho,GTPases, rho,P21, rho Protein,rho G Proteins,rho GTP Binding Protein,rho GTP Binding Proteins,rho Small GTP Binding Proteins |
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| D020764 |
cdc42 GTP-Binding Protein |
A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47. |
G25K GTP-Binding Protein, Placental Isoform,G25K Protein,cdc42 Protein,p21 cdc42,Cell Division Control Protein 42 Homolog,Cell Division Cycle 42 Protein,G25K GTP-Binding Protein,G25K GTP Binding Protein,G25K GTP Binding Protein, Placental Isoform,GTP-Binding Protein, G25K,GTP-Binding Protein, cdc42,cdc42 GTP Binding Protein,cdc42, p21 |
|
| D020830 |
rac1 GTP-Binding Protein |
A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASES. This enzyme was formerly listed as EC 3.6.1.47. |
TC-25 GTP-Binding Protein,rac1 Protein,ras-Related C3 Botulinum Toxin Substrate 1,GTP-Binding Protein, TC-25,GTP-Binding Protein, rac1,TC 25 GTP Binding Protein,rac1 GTP Binding Protein,ras Related C3 Botulinum Toxin Substrate 1 |
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