Biomaterial Database

The effect of hyperthermia on intracellular K+ in Chinese hamster ovary cells. 1987

D A Bates, and W J MacKillop

McGill Cancer Center, McGill University, Montreal, Canada.

The effect of hyperthermia on intracellular K+ concentrations was studied in Chinese hamster ovary (CHO) cells in vitro, using a flame photometer. Intracellular K+ concentrations decreased with increasing exposure time at temperatures from 40 degrees C to 45 degrees C. The decrease in K+ concentrations preceded any loss of reproductive capability at 43 degrees C and also occurred at the non-lethal temperature of 40 degrees C. Prolonged exposure to 45 degrees C resulted in an irreversible decrease in K+ concentrations. The decrease in K+ concentrations at elevated temperatures was not accounted for by changes in cell volume, loss of cells or failure of the Na+/K+ pump.

UI	MeSH Term	Description	Entries
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002460	Cell Line	Established cell cultures that have the potential to propagate indefinitely.	Cell Lines,Line, Cell,Lines, Cell
D002470	Cell Survival	The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.	Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

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