Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier. 2023

Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
Department of Physics and Chemistry-Emilio Segrè, University of Palermo, 90128 Palermo, Italy.

Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, if they have targeting properties towards a specific cellular target. Humanized Archaeoglobus fulgidus Ferritin (HumAfFt) is an engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of the hyperthermophile Archaeoglobus fulgidus ferritin and is successfully endowed with the human H homopolymer recognition sequence by the transferrin receptor (TfR1 or CD71), overexpressed in many cancer cells in response to the increased demand of iron. For this reason, HumAfFt was successfully used in this study as a coating material for 10 nm SPIONs, in order to produce a new magnetic nanocarrier able to discriminate cancer cells from normal cells and maintain the potential theragnostic properties of SPIONs. HumAfFt-SPIONs were exhaustively characterized in terms of size, morphology, composition, and cytotoxicity. The preferential uptake capacity of cancer cells toward HumAfFt-SPIONs was demonstrated in vitro on human breast adenocarcinoma (MCF7) versus normal human dermal fibroblast (NHDF) cell lines.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D005293 Ferritins Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types. Basic Isoferritin,Ferritin,Isoferritin,Isoferritin, Basic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000082662 Magnetic Iron Oxide Nanoparticles Synthesized nanoparticles related to iron oxide crystalline structures with magnetic properties useful for biomedical applications. Examples include hematite, magnetite and maghemite nanoparticles. Hematite Nanoparticles,IONPs,Iron Oxide Nanoparticles,Maghemite Nanoparticles,Magnetic IONPs,Magnetic Iron Nanoparticles,SPIONs,Superparamagnetic Iron Nanoparticles,Superparamagnetic Iron Oxide Nanoparticles,Hematite Nanoparticle,IONP, Magnetic,IONPs, Magnetic,Iron Nanoparticle, Magnetic,Iron Nanoparticle, Superparamagnetic,Iron Oxide Nanoparticle,Maghemite Nanoparticle,Magnetic IONP,Magnetic Iron Nanoparticle,Nanoparticle, Hematite,Nanoparticle, Iron Oxide,Nanoparticle, Maghemite,Nanoparticle, Magnetic Iron,Nanoparticle, Superparamagnetic Iron,Nanoparticles, Hematite,Nanoparticles, Iron Oxide,Nanoparticles, Maghemite,Nanoparticles, Magnetic Iron,Nanoparticles, Superparamagnetic Iron,Superparamagnetic Iron Nanoparticle
D058185 Magnetite Nanoparticles Synthesized magnetic particles under 100 nanometers used in many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds. Magnetite SPIONs,Magnetite Superparamagnetic Iron Oxide Nanoparticles,Superparamagnetic Magnetite Nanoparticles,Magnetite Nanoparticle,Magnetite Nanoparticle, Superparamagnetic,Magnetite Nanoparticles, Superparamagnetic,Magnetite SPION,Nanoparticle, Magnetite,Nanoparticle, Superparamagnetic Magnetite,Nanoparticles, Magnetite,Nanoparticles, Superparamagnetic Magnetite,SPION, Magnetite,SPIONs, Magnetite,Superparamagnetic Magnetite Nanoparticle
D060328 Magnetic Phenomena Characteristics, properties, and effects of magnetic substances and magnetic fields. Magnetic Phenomenon,Phenomena, Magnetic,Phenomenon, Magnetic

Related Publications

Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
November 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
February 2019, International journal of pharmaceutics,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
June 2019, Research in pharmaceutical sciences,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
September 2021, Journal of drug targeting,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
January 2021, Frontiers in pharmacology,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
December 2019, Journal of nanoscience and nanotechnology,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
July 2008, Nanotechnology,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
July 2021, Molecules (Basel, Switzerland),
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
December 2017, Nanoscale,
Luisa Affatigato, and Mariano Licciardi, and Alessandra Bonamore, and Annalisa Martorana, and Alessio Incocciati, and Alberto Boffi, and Valeria Militello
June 2013, Journal of biomedical nanotechnology,
Copied contents to your clipboard!