-transparent.png){kind=logo}
Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.
Related Publications
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
February 1991,
Japanese journal of cancer research : Gann,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
January 1992,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
July 1990,
Environmental health perspectives,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
January 2024,
Mutation research. Genetic toxicology and environmental mutagenesis,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
December 1996,
Mutation research,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
May 1999,
Carcinogenesis,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
February 1998,
Cancer letters,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
November 1994,
Cancer letters,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
February 1990,
Carcinogenesis,
H Kasai, and
S Nishimura, and
Y Kurokawa, and
Y Hayashi
February 1995,
Carcinogenesis,
